Police have appealed for information after a house on Main Road was broken into between 6pm and 10pm.
After going out for the evening, the sole resident of the property, a 60-year-old woman, had returned to the property at about 10pm.
The culprits broke a window at the rear of the house to gain entry and stole a three-figure sum of cash, a computer, a television and jewellery - much of which had great sentimental value - belonging to the homeowner.
The distraught resident, who asked not to be named, said: "I came home at about 10pm and I couldn't believe what I was seeing.
"My home was a mess. They had broken a window at the back of the house and had pulled out all of my drawers.
"They took all of my jewellery. I'm 60 years old and a lot of my pieces were gifts from my family that I have collected over the years.
"I've lived here for 13 years and nothing like this has ever happened before.
"My neighbours took me in and were kind enough to let me stay with them on Monday night."
A Lothian and Borders Police spokesman confirmed that the Main Road property was the only residence targeted by the thieves that evening.
He said: "We are investigating following a housebreaking and theft from a property in Dirleton.
"Anyone who was in the area and witnessed anything suspicious,
or who has information that can assist with police enquiries, is asked
to contact Lothian and Borders Police immediately on 0131 311 3131 or call Crimestoppers on 0800 555111."